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Rabbit Anti-IPP/Gold Conjugated antibody (bs-16686R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-16686R-Gold
英文名稱 Rabbit Anti-IPP/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的肌動(dòng)蛋白結(jié)合蛋白IPP抗體
別    名 Actin binding protein IPP; Intracisternal A particle promoted polypeptide; IPP POZ; IPP_HUMAN; Kelch like protein 27; KLHL27; MIPP protein;  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IPP
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Function:
Intracisternal A particle promoted polypeptide (IPP) is a member of the kelch family of proteins, characterized by a 50 amino acid repeat which interacts with actin. The kelch domain of IPP consists of six C terminal tandem arranged repeats. IPP may play a role in organizing the actin cytoskeleton. IPP also contains an N terminal POZ protein protein interaction domain. The POZ domain (also called BTB domain) is present near the N terminus of a fraction of zinc finger proteins and in proteins that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co repressor complexes including N-coR and SMRT.

Subcellular Location:
Cytoplasm, cytoskeleton.

Similarity:
Contains 1 BTB (POZ) domain. {ECO:0000255|PROSITE-ProRule:PRU00037}.
Contains 6 Kelch repeats. {ECO:0000305}.

Database links:

Entrez Gene: 3652 Human

Entrez Gene: 785293 Cow

Entrez Gene: 16351 Mouse

Entrez Gene: 298439 Rat

Omim: 147485 Human

SwissProt: Q9Y573 Human

SwissProt: P28575 Mouse

Unigene: 699548 Human

Unigene: 229516 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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