產(chǎn)品編號 | bs-10327R-BF555 |
英文名稱 | Rabbit Anti-Phospho-HDAC7(Ser155)/BF555 Conjugated antibody |
中文名稱 | BF555標(biāo)記的磷酸化組蛋白去乙?;?抗體 |
別 名 | HDAC7 (phospho S155); HDAC7 (phospho Ser155); p-HDAC7 (Ser155); HD 7a; HD7a; HDAC 7; HDAC 7A; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A; DKFZP586J0917; OTTHUMP00000202813; OTTHUMP00000202814; FLJ99588; HDAC7_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 119kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human HDAC7 around the phosphorylation site of Ser155 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Subunit: Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15. Interacts with PML (isoform PML-4). Subcellular Location: Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. Post-translational modifications: May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181. Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily. Database links: Entrez Gene: 51564 Human Entrez Gene: 56233 Mouse Omim: 606542 Human SwissProt: Q8WUI4 Human SwissProt: Q8C2B3 Mouse Unigene: 200063 Human Unigene: 384027 Mouse Unigene: 203327 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 红桃视频成人A片免费播放 国产91 丝袜在线播放 | 国产无码高清在线观看 | 性爱插插插动态图120秒免费看 | 一区二区三区高清无码 | 精品秘 一区二三区免费雷安胖子 | 中文字幕-区二区三区四区视频 | 好吊一区二区三区 | 国产丰满大乳无码免费播放 | 亚洲AV无码乱码在线观看性色 | 四季岛国AV无码一区 | 精品国产乱码久久久久久88AV | 电影av免费一区 | 七十路の高齢熟妇无码 | 国产成人a亚洲精品久久久久 | 久久成人网一区二区青椒直播 | 91午夜理伦私人影院 | 国产欧美日韩在线观看 | 中文av乱码字幕网站在线观看 | 国产suv精品一区二区 | 免费很黄很爽很污入口 | 国产黄色小视频在线观看 | 強暴強姦AV正片一区二区三区 | 91久久精品无码一区二区毛片进 | 又大又硬又粗高潮视频 | 成人精品一区二区三区A片用毒蛇 | 国产无码一区二区三区四区 | 欧美乱妇无乱码大黄A片 | 亚洲熟妇白浆无码AV在线 | 亚洲无码成人在线观看 | 狠狠色综合7777之夜色撩人 | 99久久婷婷国产一区二区三区 | 国产暴力强伦轩人妻 | 精品国产乱码久久久久久免费舒淇 | av高清无码在线观看 | 脫衣舞一区二区三区 | 国产呻吟精品高潮久久AV无码 | 久久久久久久久成人精品视频 | 国产一级毛片精品A片在线美传媒 | 国产奶头好大揉着好爽视频 | 国产精品久久久久久久久无码春色 |