| 產(chǎn)品編號(hào) | bs-12029R-BF488 |
| 英文名稱 | Rabbit Anti-GPRC5B/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的G蛋白偶聯(lián)受體C5B抗體 |
| 別 名 | A 69G12.1; A-69G12.1; G protein coupled receptor family C group 1 member B; G protein coupled receptor family C group 5 member B; G-protein coupled receptor family C group 5 member B; GPC5B_HUMAN; Gprc5b; LOC51704; RAIG-2; RAIG2; Retinoic acid responsive gene protein; Retinoic acid-induced gene 2 protein; GPCR GPRC5B. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human G protein coupled receptor family C group 1 member B |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: GPRC5B (G protein-coupled receptor family C group 5 member B, retinoic acid-induced gene 2 protein) is a 403 amino acid protein encoded by the human GPRC5B gene. GPRC5B is an orphan receptor member of the G protein-coupled receptor 3 family. G protein-coupled receptors (GPCRs or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Key roles for G protein-coupled receptors include control of protein maturation and cell surface delivery, and providing the correct framework for interactions with both heterotrimeric G proteins and arrestins to allow signal generation and termination. This retinoic acid-inducible G protein-coupled receptor provides evidence for a possible interaction between retinoid and G protein signaling pathways. GPRC5B is highly expressed in kidney, pancreas and testis, and has moderate expression in brain, heart, prostate, small intestine and spleen. Function: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Subcellular Location: Cell membrane. Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles. Tissue Specificity: Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach. Similarity: Belongs to the G-protein coupled receptor 3 family. Database links: Entrez Gene: 51704 Human Entrez Gene: 64297 Mouse Omim: 605948 Human SwissProt: Q9NZH0 Human SwissProt: Q923Z0 Mouse Unigene: 148685 Human Unigene: 103439 Mouse Unigene: 47330 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
