| 產(chǎn)品編號(hào) | bs-11851R-Gold |
| 英文名稱 | Rabbit Anti-HELT/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的轉(zhuǎn)錄因子HELT蛋白抗體 |
| 別 名 | Hairy and enhancer of split-related protein HELT; HCM1228; HELT; HELT_HUMAN; HES like ; HES/HEY like transcription factor; HES/HEY-like transcription factor; HESL; Heslike ; Hey like transcription factor; Hey like transcription factor (zebrafish); Hey like transcriptional repressor; Megane bHLH factor; Mgn. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Zebrafish, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HELT |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The Notch signaling pathway is thought to maintain stem cells through transcriptional activation of HES/HEY family members to repress tissue-specific transcription factors. HESL (HES-like), also known as Mgn or HELT (HES/HEY-like transcription factor), is a 327 amino acid nuclear protein belonging to the HEY family. Containing a basic helix-loop-helix (bHLH) domain and an Orange domain, HESL self-associates and interacts with HES5 and HRT2. HESL is considered a transcriptional repressor that binds to the canonical E box sequence 5'-CACGCG-3'. HESL exists as two isoforms produced by alternative splicing events. Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Subunit: Self-associates. Interacts with HES5 and HEY2 Subcellular Location: Nucleus. Similarity: Belongs to the HEY family. Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. Database links: UniProtKB/Swiss-Prot: A6NFD8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
