| 產(chǎn)品編號(hào) | bs-5948R-Gold |
| 英文名稱 | Rabbit Anti-CIP2A/p90 Autoantigen/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的蛋白磷酸酶PP2A癌抑制蛋白抗體 |
| 別 名 | p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 100kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human p90 Autoantigen |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. Subunit: Interacts with MYC. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region. Tissue Specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). Database links: Clone ID: 57650 Human Entrez Gene: 57650 Human Entrez Gene: 224171 Mouse Omim: 610643 Human SwissProt: Q8TCG1 Human SwissProt: Q8BWY9 Mouse Unigene: 591308 Human Unigene: 24491 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
