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Rabbit Anti-IMPDH2/Gold Conjugated antibody (bs-5924R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-5924R-Gold
英文名稱 Rabbit Anti-IMPDH2/Gold Conjugated antibody
中文名稱 膠體金標記的5'肌苷磷酸脫氫酶2抗體
別    名 IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH-II; Impdh2; IMPDHII; Inosine 5' monophosphate dehydrogenase 2; Inosine-5''-monophosphate dehydrogenase 2; IMDH2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  免疫學  信號轉導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IMPDH2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Subunit:
Homotetramer.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Database links:

Entrez Gene: 3615 Human

Entrez Gene: 23918 Mouse

Entrez Gene: 301005 Rat

Omim: 146691 Human

SwissProt: P12268 Human

SwissProt: P24547 Mouse

SwissProt: E9PU28 Rat

Unigene: 654400 Human

Unigene: 6065 Mouse

Unigene: 8093 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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