產(chǎn)品編號 | bs-5680R-HRP |
英文名稱 | Rabbit Anti-phospho-RPS6KA1(Thr348)/HRP Conjugated antibody |
中文名稱 | 辣根過氧化物酶標(biāo)記的磷酸化磷酸化絲氨酸/蘇氨酸激酶p90RSK蛋白抗體 |
別 名 | p90RSK(Phospho-Thr348); RPS6KA1(phospho T348); p90 RSK1 ; p90rsk ; p90S6K ; pp90RSK1 ; Ribosomal protein S6 kinase 90kD 1 ; Ribosomal protein S6 kinase 90kD polypeptide 1 ; Ribosomal protein S6 kinase 90kDa polypeptide 1 ; Ribosomal protein S6 kinase alpha 1 ; Ribosomal protein S6 kinase polypeptide 1 ; Ribosomal S6 kinase 1 ; RPS6K1 alpha ; rps6ka ; Rps6ka1 ; RSK 1 ; RSK 1 p90 ; RSK ; RSK1 ; S6K alpha 1 ; 90 kDa ribosomal protein S6 kinase 1 ; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 ; dJ590P13.1 ; EC 2.7.11.1 ; HU 1 ; HU1 ; MAP kinase activated protein kinase 1a ; MAPKAP kinase 1A ; MAPKAPK1A ; MGC79981 ; Mitogen-activated protein kinase-activated protein kinase 1A; KS6A1_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, ) |
產(chǎn)品應(yīng)用 | ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 81kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human RPS6KA1 around the phosphorylation site of Thr348 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB. Function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Subunit: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1. Subcellular Location: Nucleus. Cytoplasm. Post-translational modifications: Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains. Database links: Entrez Gene: 6195 Human Entrez Gene: 20111 Mouse Omim: 601684 Human SwissProt: Q15418 Human SwissProt: P18653 Mouse Unigene: 149957 Human Unigene: 301827 Mouse Unigene: 34915 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. p90RSK蛋白屬于廣泛表達(dá)的絲氨酸/蘇氨酸激酶。RSK家族包括RSK1、RSK2、RSK3和RSK4,它們的典型特征是含有兩個不同的功能性激酶結(jié)構(gòu)域和羧基端ERKs(extracellular signal-regulated kinases)結(jié)合結(jié)構(gòu)域。RSK激酶結(jié)構(gòu)域內(nèi)外的幾個位點包括Ser380、Thr359、Ser363和Thr573的磷酸化都對RSK的激酶活性激活非常重要。 RSK1-3可被MAPKs所磷酸化激活,也可以通過自身磷酸化激活,還可被一些生長因子或神經(jīng)遞質(zhì)等誘導(dǎo)激活的PI3K信號通路所激活。RSK在被MAPK磷酸化激活時,是由Ras、Raf-1、MAP kinase kinase(MEK)和MAP kinase信號通路所介導(dǎo)。PI3K誘導(dǎo)的RSK1激活是由絲氨酸/蘇氨酸激酶mTOR介導(dǎo)的。 RSK1在葡萄糖穩(wěn)態(tài)調(diào)控和細(xì)胞大小的調(diào)控中起重要作用。RSK可以磷酸化并調(diào)節(jié)轉(zhuǎn)錄因子c-fos和糖原合成酶激酶3(GSK3,glycogen synthase kinase 3)的活性。有報道RSK1可以和MAPK1、IκBα、TOB和TSC2等相互作用。RSK可以在有絲分裂信號刺激下會轉(zhuǎn)位到細(xì)胞核內(nèi)。 |
| 国产无套精品一区二区 | 内射后入美女屁屁网站 | 久久久无码喷水日本动漫一区二区 | 国产视频秘 福利姬在线 | 国产精品久久久久久一级毛片 | 国产一级精品绿帽视频 | 欧美与黑人午夜性猛交久久久 | 欧美人妇做爰A片免费看 | 中国一级片在线播放 | 国产午夜精品一区二区三区嫩草 | 国产精品久久久久影院老司 | 国产精品无码免费视频 | 国产又爽 又黄 免费视频两年半 | 欧美搡大BBBB流水 | 国产一区二区三区无码 | 69国产探花在线观看 | 99无码秘 蜜桃人妻一区二区三区 | 人妻少妇偷人精品无码 | 四川性BBB搡BBB爽爽爽小说 | 亚洲精品AV丰滿 | 国产熟妇婬乱A片免费看牛牛 | 国产一级a毛一级a看免费视频乱 | 亚洲精品一区久久久久久 | 国产aV熟妇人震精品 | 国产精品久久久精品影视 | 人人爱人人摸人人操 | 精品人妻一区二区三区四区色欲 | 国产日韩免费高清视频 | 国产黄色红桃视频二区 | 国产91色欲麻豆精品一区二区 | 黃色A片三級三級三級免费看蜜 | 天天日天天干天天插1 | 一本ww高清免费 | 成人在线免费观看视频 | 91AV变态在线视频 | 无人码人妻一区二区三区免费 | 精品动漫中文子幕三区 | 国产午夜精品一区二区 | 国产精品传媒无码成人猛烈 | 亚洲精品久久久久久久久久久 |