| 產(chǎn)品編號(hào) | bs-0711R-AP |
| 英文名稱 | Rabbit Anti-FAM3B/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的胰腺衍生因子抗體 |
| 別 名 | C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞凋亡 糖尿病 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAM3B |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family. Function: Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Subcellular Location: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure. Tissue Specificity: Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. Post-translational modifications: 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. O-glycosylated. Similarity: Belongs to the FAM3 family. Database links: Entrez Gene: 54097 Human Entrez Gene: 52793 Mouse Omim: 608617 Human SwissProt: P58499 Human SwissProt: Q9D309 Mouse Unigene: 473877 Human Unigene: 670704 Human Unigene: 327932 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰腺衍生因子（PANcreatic DERived fa*ctor，PANDER）是新發(fā)現(xiàn)的一種新型的胰島細(xì)胞因子、由胰島α細(xì)胞和β細(xì)胞分泌的一種分泌型細(xì)胞因子，與β細(xì)胞凋亡密切相關(guān) ，可以誘導(dǎo)胰島素分泌β細(xì)胞，主要用于糖尿病的研究。 |
