| 產(chǎn)品編號 | bs-3119R-HRP |
| 英文名稱 | Rabbit Anti-Phospho-DARPP32 (Thr75)/HRP Conjugated antibody |
| 中文名稱 | 辣根過氧化物酶標(biāo)記的磷酸化多巴胺/cAMP調(diào)節(jié)磷蛋白抗體 |
| 別 名 | DARPP32 (phospho T75); p-DARPP32 (phospho T75); PPP1R1B(phospho T75); DARPP 32; Dopamine and cAMP regulated neuronal phosphoprotein; Dopamine and cAMP regulated phosphoprotein DARPP 32; Dopamine and cAMP regulated phosphoprotein DARPP32; FLJ20940; IPPD; Neuronal phosphoprotein DARPP 32; PPP1R1B; Protein phosphatase 1 regulatory (inhibitor) subunit 1B; Protein phosphatase 1 regulatory subunit 1B; PPR1B_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, ,G) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human DARPP32 around the phosphorylation site of Thr75 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Function: Inhibitor of protein-phosphatase 1. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation of Thr-34 is required for activity. Similarity: Belongs to the protein phosphatase inhibitor 1 family. Database links: Entrez Gene: 84152 Human Entrez Gene: 19049 Mouse Omim: 604399 Human SwissProt: Q9UD71 Human SwissProt: Q60829 Mouse Unigene: 286192 Human Unigene: 45372 Mouse Unigene: 70366 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DARPP-32通過自身不同位點(diǎn)的磷酸化對蛋白質(zhì)磷酸化和去磷酸化過程發(fā)揮著雙向調(diào)控的作用.DARRP-32在腦內(nèi)存在于接受多巴胺能投射的神經(jīng)元中,其磷酸化過程受多種神經(jīng)遞質(zhì)的調(diào)控,在信號轉(zhuǎn)導(dǎo)途徑中處于中心位置,整合多種胞內(nèi)信號轉(zhuǎn)導(dǎo),調(diào)節(jié)神經(jīng)元的電學(xué)和化學(xué)性質(zhì)以及動物的生理行為反應(yīng),參與多種生理功能和病理過程,包括藥物成癮、抑郁癥、精神分裂癥等.此外,DARPP-32在非神經(jīng)系統(tǒng)的功能也逐漸被人們所認(rèn)識. 多巴胺和cAMP調(diào)節(jié)的磷蛋白(dopamine and adenosine 3'5'-monophosphate-regulated phospho-protein,Mr 32 kD,DARPP-32)是一個具有雙重功能的獨(dú)特蛋白,它既是磷酸酶(如PP-1)的抑制劑,也是蛋白激酶(如PKA)的抑制劑。 |
