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Rabbit Anti-Dab1/Gold Conjugated antibody (bs-11547R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11547R-Gold
英文名稱 Rabbit Anti-Dab1/Gold Conjugated antibody
中文名稱 膠體金標記的磷脂蛋白受體Dab1抗體
別    名 Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari; Dab, reelin signal transducer, homolog 1 (Drosophila); Dab1; DAB1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dab1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Function:
Adapter molecule functioning in neural development. May regulate SIAH1 activity.

Subunit:
Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1.

Post-translational modifications:
Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.

Similarity:
Contains 1 PID domain.

Database links:

Entrez Gene: 1600 Human

Entrez Gene: 13131 Mouse

Entrez Gene: 266729 Rat

Entrez Gene: 374083 Chicken

Omim: 603448 Human

SwissProt: O75553 Human

SwissProt: P97318 Mouse

SwissProt: Q8CJH2 Rat

Unigene: 477370 Human

Unigene: 289682 Mouse

Unigene: 206534 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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