產(chǎn)品編號 | bsm-52238R |
英文名稱 | STAT5b Recombinant Rabbit mAb |
中文名稱 | 信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5b重組兔單抗 |
別 名 | Transcription factor STAT5B; Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5. |
研究領(lǐng)域 | 腫瘤 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
抗體來源 | Rabbit |
克隆類型 | Recombinant |
克 隆 號 | 12A1 |
交叉反應(yīng) | Human (predicted: Mouse,Rat) |
產(chǎn)品應(yīng)用 | WB=1:1000-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 90 kDa |
檢測分子量 | |
細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | Recombinant human STAT5b protein, around 500-600aa |
亞 型 | |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR. Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. SWISS: P51692 Gene ID: 6777 Database links: Entrez Gene: 6777 Human Entrez Gene: 20851 Mouse Omim: 604260 Human SwissProt: P51692 Human SwissProt: P42232 Mouse Unigene: 595276 Human Unigene: 34064 Mouse Unigene: 54486 Rat |
產(chǎn)品圖片 | |
| 欧美日韩国产一二三区 | 午夜天堂精品久久久久 | 夜夜躁精品AAAAXXXX | 国产乱婬AAAA片视频 | 亚洲精品久久久久久久久久飞鱼 | 亚洲精品成人a v无码 | 午夜精品A片一区二区三区老狼 | 高清无码少妇一区二区 | 国产成人精品AA毛片 | 骚穴少妇高潮迭起不卡 | 中文字幕A片无码免费看 | 在线观看国产高清无码 | 黄色视频免费看大全 | 亚洲男人天堂AV | 午夜一级毛片一级A片一级AⅤ人 | 成人一区二区三中文破解版新视 | 欧美福利老妇女操大逼 | 18一20岁一级毛片 | 成人在线免费视频 | 影音先锋一区二区三区 | 国产丝袜视频在线观看 | 亚洲国产精品无码久久一区二区三区 | 又大又粗又黄色的视频 | 无码又爽又黄又刺激A片文章 | 成人无码区免费A片视频野外 | 大学生依人在线视频精品 | 色视频二区最新视频 | 免费看A片奶出水 | 丰满熟女人妻中出系列 | 久久久亚洲综合久久久久久 | 69精品人妻一区二区三区蜜桃乛 | 一级A片人妻丰满熟女1024 | 精品国产精品三级精品AV网址 | 少妇全程高潮喷水WWW久久 | 亚洲无码AV高清 | 漂亮女大学一级毛片视频 | 中文字字幕在线中文乱码修改方法 | 精品韩国AV无码一区 | 人人澡人人妻丰满熟妇 | 在线观看你懂的高潮 |