91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产裸体美女永久免费无遮挡,特级西西西4444大胆无码,亚洲成人无码av
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
phospho-IRF3 (Ser386) Recombinant Rabbit mAb (bsm-52170R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
25ul/800.00元
50ul/1400.00元
100ul/2500.00元
大包裝/詢價

產(chǎn)品編號 bsm-52170R
英文名稱 phospho-IRF3 (Ser386) Recombinant Rabbit mAb
中文名稱 磷酸化干擾素調(diào)節(jié)因子3重組兔單抗
別    名 IRF3(S386); IRF3(phospho S386); IRF3(phospho Ser386); p-IRF3(Ser386); p-IRF3(S386); Interferon regulatory factor 3; IRF 3; IRF-3; IRF3; IRF3_HUMAN; MGC94729.  
Specific References  (1)     |     bsm-52170R has been referenced in 1 publications.
[IF=4.165] Shenjie Zhong. et al. Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Commun Biol. 2021 Mar;4(1):1-15  WB ;  Zebrafish.  
產(chǎn)品類型 磷酸化抗體 重組兔單抗 
研究領(lǐng)域 腫瘤  細胞生物  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號 28C3
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:50-200,IF=1:50-200,ICC/IF=1:50
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 47 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRF3 around the phosphorylation site of Ser386: S(p-S)LE 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subunit:
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Tissue Specificity:
Expressed constitutively in a variety of tissues.

Post-translational modifications:
Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.
ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

SWISS:
Q14653

Gene ID:
3661

Database links:

Entrez Gene: 3661 Human

Entrez Gene: 54131 Mouse

Omim: 603734 Human

SwissProt: Q14653 Human

SwissProt: P70671 Mouse

Unigene: 289052 Human

Unigene: 75254 Human

Unigene: 3960 Mouse



產(chǎn)品圖片
MCF7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer(normal goat serum) at 37°C for 20 min; Antibody incubation with (Phospho-IRF3(S386) ) monoclonal Antibody, Unconjugated (bsm-52170R) 1:50, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
版權(quán)所有 2004-2026 rvdoil.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
美女淫荡视频网站免费观看 | 久产久人精午夜精国 | 白峰人妻系列在线观看 | 波多野结衣无码视频 | 人妻中文字幕蜜美杏超绝伦 | 中文字幕日韩精品无码内射 | 国产欧美一区二区色老头 | 亚洲AV无码免费在线观看 | 亚洲精品无码久久久香草影院 | 人人澡超碰碰97碰碰碰 | 国产又粗又猛又黄又爽无遮挡 | wwyw913国产成人精品 | 丰满人妻在公交车上的激情 | 日韩人妻无码一区二区 | 熟妇少妇自拍偷拍第五页 | 成av人片一区二区三区久久 | 久久一区二区三区精品 | 亚洲精品无码久久 | 国产精品昆明久久久综合888 | 又粗又大又黄免费视频 | 少妇毛片一区二区三区粉嫩aV | 国产小骚货性爱在线观看 | 亚洲色婷婷综合久久二区 | 日韩精品一区二区三区 | 亚洲精品一区二区潘金莲 | 欧美,日韩,国产黄图91块 | 日本韩国成人网站 | 国产91亚洲精品成人AA片p站 | 在线视频2018二页 | 中文字幕无码在线 | 精品久久BBBBB精品人妻 | 国产xXx69麻豆国语对白 | 国产大波美女在线免费观看 | 国产自产精品一区精品 | 国产精品人妻一期二期三期四期 | 最近最好看的2018中文字幕电视剧 | 影音先锋在线观看资源网 | 亚洲精品成人免费视频网站 | √资源天堂中文在线视频 | 成人一区二区三中文破解版新视 | 秋霞电影网操性感女人 |