| 產(chǎn)品編號(hào) | bsm-51379M |
| 英文名稱 | CGAS Mouse mAb |
| 中文名稱 | MB21D1 單克隆抗體 |
| 別 名 | Mab-21 Domain Containing 1; Mab-21 Domain-Containing Protein 1; Cyclic GMP-AMP Synthase; 23-CGAMP Synthase; CGAMP Synthase; C6orf150; H-CGAS; Chromosome 6 Open Reading Frame 150; Protein MB21D1; EC 2.7.7.86; CGAS_HUMAN; Hypothetical protein LOC115004; MB2 |
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Specific References (1) | bsm-51379M has been referenced in 1 publications.
[IF=7.129] Xiaofei Wang. et al. Selenomethionine mitigate PM2.5-induced cellular senescence in the lung via attenuating inflammatory response mediated by cGAS/STING/NF-κB pathway. ECOTOX ENVIRON SAFE. 2022 Dec;247:114266 IF ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | 7000 |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:500-5000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 59 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MB21D1/ C6orf150 |
| 亞 型 | IgG1 |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
MB21D1 (Mab-21 Domain Containing 1) is a Protein Coding gene. Diseases associated with MB21D1 include Aicardi-Goutieres Syndrome and Renpenning Syndrome. Among its related pathways are Innate Immune System and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include GTP binding and cyclic-GMP-AMP synthase activity. Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2,5 phosphodiester linkage at the GpA step and the formation of a 3,5 phosphodiester linkage at the ApG step, producing c[G(2,5)pA(3,5)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). (Microbial infection) Upon M.tuberculosis infection THP-1 cells knocked-out for this gene have impaired type-I interferon production (IF-1 beta), nor do they produce type-I IFN upon transfection with dsDNA (PubMed:26048138). Subcellular Location: Cytoplasm, cytosol. Tissue Specificity: Expressed in the monocytic cell line THP1. Similarity: Belongs to the mab-21 family. SWISS: Q8N884 Gene ID: 115004 Database links: Entrez Gene: 115004 Human Omim: 613973 Human SwissProt: Q8N884 Human Unigene: 658405 Human |
