| 產(chǎn)品編號(hào) | bs-18859R |
| 英文名稱 | RRP4 Rabbit pAb |
| 中文名稱 | RRP4蛋白抗體 |
| 別 名 | EXOSC2; Exosome complex exonuclease RRP4; Exosome component 2; hRrp4p; OTTHUMP00000022370; OTTHUMP00000022371; OTTHUMP00000022372; OTTHUMP00000022373; OTTHUMP00000022374; p7; Ribosomal RNA processing protein 4; RRP4; Rrp4p. |
| 研究領(lǐng)域 | 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Zebrafish,Chicken,Dog,Horse, Macaque Monkey,Rhesus monkey,Gorilla,Opossum,Marmoset (common)) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRP4: 51-150/293 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Rrp4 and Ski7p are components of the cytoplasmic exosome complex, and together with the RNA helicase Ski2p they are necessary for degradation of deadenylated mRNA. Rrp4 is required for the 3’ to 5’ exonuclease activity that produces the 3’ end of the 5.8S rRNA. Rrp4 also functions as a subunit of the specialized trypanosome exosome complex. Function: The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3'-5' exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism. Subcellular Location: Cytoplasmic, Exosome and Nuclear Similarity: Belongs to the RRP1 family. SWISS: Q13868 Gene ID: 23404 Database links: Entrez Gene: 101126796 Gorilla Entrez Gene: 23404 Human Entrez Gene: 100397822 Marmoset (common) Entrez Gene: 227715 Mouse Entrez Gene: 100439017 Orangutan Entrez Gene: 595050 Xenopus tropicalis GenBank: NP_055100.2 Human Omim: 602238 Human SwissProt: Q13868 Human SwissProt: Q8VBV3 Mouse Unigene: 654643 Huma |
