| 產(chǎn)品編號 | bs-11848R |
| 英文名稱 | GPR56 Rabbit pAb |
| 中文名稱 | 蛋白偶聯(lián)受體56抗體 |
| 別 名 | BFPP; DKFZp781L1398; EGF TM7 like; G protein coupled receptor 56; GPR 56; Polymicrogyria bilateral frontoparietal; TM7LN4; TM7XN1; TM7XN1 protein; GPR56_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞膜受體 G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 78 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR56: 275-350/693 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. G-protein coupled receptor 56 (GPR56), also designated TM7XN1 protein, contains one GPS domain. GPR56 plays an important role in cell-cell interactions and is widely expressed, with highest levels detected in brain, heart and thyroid gland. Defects in the gene encoding for GPR56 can cause bilateral frontoparietal polymicrogyria (BFPP) which is characterized by disorganized cortical lamination. Function: GPR56 contains 7 transmembrane domains as well as a mucin-like domain and cysteine box in the N-terminal region. Its expression is widely distributed and the highest levels can be found in brain, thyroid gland and heart. It is also expressed in a great number of tumor cells. Results show that mutations in GPR56 cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria (BFPP); data suggest that GPR56 signaling plays an essential role in regional development of human cerebral cortex. Subcellular Location: Cell membrane. Multi-pass membrane protein. Tissue Specificity: Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Post-translational modifications: The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. DISEASE: Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP) [MIM:606854]. BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. SWISS: Q9Y653 Gene ID: 9289 Database links: Entrez Gene: 9289 Human Entrez Gene: 14766 Mouse Omim: 604110 Human SwissProt: Q9Y653 Human SwissProt: Q8K209 Mouse Unigene: 513633 Human Unigene: 290834 Mouse Unigene: 1677 Rat |
| 產(chǎn)品圖片 |
Sample:
K562 Cell (Human) Lysate at 40 ug
Heart (Mouse) Lysate at 40 ug
Primary: Anti-GPR56 (bs-11848R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 78 kD
Observed band size: 75 kD
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