產(chǎn)品編號(hào) | bs-11015R |
英文名稱 | BFSP2 Rabbit pAb |
中文名稱 | 晶狀體蛋白2抗體 |
別 名 | 49 kDa cytoskeletal protein; Beaded filament protein CP49; Beaded filament structural protein 2; Beaded filament structural protein 2, phakinin; Bfps2, Cytoskeletal protein, 49 kD; BFSP2; BFSP2_HUMAN; CP47; CP49; Lens fiber cell beaded filament protein CP |
研究領(lǐng)域 | 神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞骨架 |
抗體來(lái)源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human,Mouse,Rat,Dog) |
產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 46 kDa |
檢測(cè)分子量 | |
細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human BFSP2/Phakinin: 181-280/415 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
Phakinin is a membrane-associated and cytoskeletal intermediate filament (IF) protein specific to the eye lens. IFs are cytoskeletal structures that typically contain a head, rod and tail domain. Unlike most IFs, Phakinin completely lacks the C-terminal tail domain thus contributing to the unique structure of the beaded filament that is specific to the lens. Phakinin is required for the assembly of beaded filaments and cytoskeletal networks that are important for the long-term maintenance of optical properties and transparency of the lens. Phakinin copolymerizes with Filensin, another IF protein, to form the 10-nm filamentous structures of the beaded filaments. Phakinin is also capable of self-assembling into filament-like structures that form thicker bundles. Mutations in the gene encoding Phakinin can result in lens cataract. Function: Involved in stabilization of lens fiber cell cytoskeleton. Subunit: Associates with BFSP1. Interacts with LGSN. Subcellular Location: Membrane. Cytoplasm. Cytoplasm, cytoskeleton. Membrane- and cytoskeleton-associated. Tissue Specificity: Lens. DISEASE: Defects in BFSP2 are the cause of cataract autosomal dominant BFSP2-related (ADC-BFSP2); also known as cataract autosomal dominant multiple types 1. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract autosomal dominant BFSP2-related is characterized by a variable phenotype that may or may not be consistent within a family. The opacities can be nuclear, sutural, stellate cortical, lamellar, cortical, nuclear embryonic, Y-sutural, punctate cortical, congenital or with juvenile- and adult-onset. Similarity: Belongs to the intermediate filament family. SWISS: Q13515 Gene ID: 8419 Database links: Entrez Gene: 8419 Human Omim: 603212 Human SwissProt: Q13515 Human Unigene: 659862 Human |
| 国产又大又粗又爽的毛片 | 亚洲成人老阿姨露脸对白 | 一区二区三区少妇 | 特级毛片电影免费免费看不收钱 | AV不卡一区二区三区 | 一线大片久久久久久久久久久久久久久18 | 亚洲AV无码成人精品区国产 | 日本强伦轩人妻中文字幕 | 精品人妻无码一区二区出白浆潮喷 | 麻豆传媒黄色视频在线观看 | 无码粉嫩极品尤物在线综合 | 亚洲欧美 va天堂人熟伦 | 国产对白粗大硬爽视频 | 国产农村妇女一级A片麻豆手机版 | 欧–美–性–交–黄–片 | 国产精品精品久久久久久 | 一本色道无码人妻精品 | 波多野结衣无中码免费观看 | 欧美爆乳乱妇高清毛片 | 蜜臀98精品国产免费观看AA片 | 成人黄网站 免费入口 | AV手机免费在线观看 | 5177.tv草草影院 | 亚洲第一极品精品无码久久 | 亚洲精品乱码久久久久久蜜桃麻豆 | 强伦轩一区二区三区免费看 | www..xhs.小黄书成人网站 | 日产精品无码一级毛片 | 波多野结衣AV片免费观看 | 亚洲在线免费观看 | 百国产乱婬AV免费 | 亚洲春色一区二区三区 | 婷婷伊人綜合亞洲綜合網 | 妇欲欢公爽公妇精品一区 | 国产丰满熟妇蜜臀AV高潮 | 欧美日韩另类暴露女视频 | 日韩人妻精品无码久久 | 91色精品秘 19A片下 | 精品人妻一区二区三区蜜桃 | 四川少妇女BBB凸凸凸凸 |