| 產(chǎn)品編號(hào) | bs-4991R |
| 英文名稱 | CD32 Rabbit pAb |
| 中文名稱 | 免疫球蛋白G Fc段受體Ⅱ抗體 |
| 別 名 | CD32B; FCGR2B; IGFR2; Lym 1; CD32 antigen; CDw32; Fc fragment of IgG, low affinity II, receptor for(CD32); Fc fragment of IgG, low affinity IIb, receptor; Fc fragment of IgG, low affinity IIb, receptor(CD32); Fc fragment of IgG, low affinity IIb, receptor |
 |
Specific References (1) | bs-4991R has been referenced in 1 publications.
[IF=3.098] Linlin Sheng. et al. Overexpression of FcγRIIB regulates downstream protein phosphorylation and suppresses B cell activation to ameliorate systemic lupus erythematosus. Int J Mol Med. 2020 Oct;46(4):1409-1422 ELISA ; Human.
|
| 研究領(lǐng)域 | 免疫學(xué) 干細(xì)胞 細(xì)胞膜受體 淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD32: 101-200/310 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. Subunit: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. Post-translational modifications: Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SWISS: P31994 Gene ID: 2213 Database links: Entrez Gene: 2213 Human SwissProt: P31994 Human |
| 產(chǎn)品圖片 |
Sample:
U937(Human) Cell Lysate at 30 ug
Primary: Anti-CD32 (bs-4991R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 33 kD
|
