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KCNN4 Rabbit pAb (bs-6675R)  
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產(chǎn)品編號(hào) bs-6675R
英文名稱 KCNN4 Rabbit pAb
中文名稱 鈣激活鉀通道蛋白4抗體
別    名 hIKCa1; IK1; IKCa1; Intermediate conductance calcium activated potassium channel protein 4; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; Kcnn4; KCNN4_HUMAN; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4; Putative Gardos channel; SK4; SKCa 4; SKCa4.  
Specific References  (3)     |     bs-6675R has been referenced in 3 publications.
[IF=6.543] Liu Dishiwen. et al. Cardiac Fibroblasts Promote Ferroptosis in Atrial Fibrillation by Secreting Exo-miR-23a-3p Targeting SLC7A11. OXID MED CELL LONGEV. 2022;2022:3961495  WB ;  Dog,Rat.  
[IF=4.3] Lively et al. Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. (2018) Front.Cell.Neurosci. 12:115  WB ;  Rat.  
[IF=3.23] Zhang, Panshi, et al. "Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells." PLOS ONE 11.4 (2016): e0154471.  IHC-P ;  Human.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  通道蛋白  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNN4: 325-427/427 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Subunit:
Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed in non-excitable tissues.

Post-translational modifications:
Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.

Similarity:
Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.

SWISS:
O15554

Gene ID:
3783

Database links:

Entrez Gene: 3783 Human

Entrez Gene: 16534 Mouse

Entrez Gene: 65206 Rat

Omim: 602754 Human

SwissProt: O15554 Human

SwissProt: O89109 Mouse

SwissProt: Q9QYW1 Rat

Unigene: 10082 Human

Unigene: 9911 Mouse

Unigene: 44212 Rat



產(chǎn)品圖片
Sample: Lane 1: Human U-2 OS cell lysates Lane 2: Human U87MG cell lysates Lane 3: Human HeLa cell lysates Lane 4: Human U251 cell lysates Lane 5: Human LOVO cell lysates Lane 6: Human HepG2 cell lysates Primary: Anti-KCNN4 (bs-6675R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 45 kDa
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