| 產(chǎn)品編號(hào) | bs-5098R |
| 英文名稱 | IGFBP7 Rabbit pAb |
| 中文名稱 | 胰島素樣生長(zhǎng)因子結(jié)合蛋白7抗體 |
| 別 名 | AGM; Angiomodulin; FSTL2; IBP-7; IBP7; IBP7_HUMAN; IGF binding protein 7; IGF-binding protein 7; IGFBP rP1; IGFBP-7; IGFBP-rP1; IGFBP7; IGFBPRP1; Insulin like growth factor binding protein 7; Insulin-like growth factor-binding protein 7; MAC25; MAC25 protein; PGI2 stimulating factor; PGI2-stimulating factor; Prostacyclin stimulating factor; Prostacyclin-stimulating factor; PSF; RAMSVPS; TAF; Tumor-derived adhesion factor. |
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Specific References (1) | bs-5098R has been referenced in 1 publications.
[IF=4.268] Qin Yang. et al. Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation. Phytomedicine. 2021 Mar;:153541 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGFBP7: 131-230/282 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGFBP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGFBP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Subunit: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. Subcellular Location: Secreted. Post-translational modifications: N-glycosylated. DISEASE: Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 IGFBP N-terminal domain. SWISS: Q16270 Gene ID: 3490 Database links: Entrez Gene: 3490 Human Entrez Gene: 29817 Mouse Omim: 602867 Human SwissProt: Q16270 Human SwissProt: Q61581 Mouse Unigene: 479808 Human Unigene: 233470 Mouse Unigene: 203012 Rat |
| 產(chǎn)品圖片 |
Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human liver labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (bs-5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Positive Control has great staining, however it may be nonspecific.
Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human kidney labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (bs-5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Postive Control has great staining, however it may be nonspecific.
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