| 產(chǎn)品編號 | bs-3818R |
| 英文名稱 | GDF15 Rabbit pAb |
| 中文名稱 | 生長分化因子15/巨嗜細(xì)胞抑制因子1抗體 |
| 別 名 | GDF 15; GDF-15; GDF15_HUMAN; Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; Mic-1; MIC1; NAG 1; NAG-1; NAG1; NRG 1; NRG-1; NRG1; NSAID(nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; Placental TGF-beta; Prostate differentiation factor; PTGF beta; PTGFB. |
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Specific References (9) | bs-3818R has been referenced in 9 publications.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 細(xì)胞分化 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 12.5/34 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDF-15: 221-308/308 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects.
BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.
GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Similarity: Belongs to the TGF-beta family. SWISS: Q99988 Gene ID: 9518 Database links: Entrez Gene: 9518 Human Entrez Gene: 23886 Mouse Omim: 605312 Human SwissProt: Q99988 Human SwissProt: Q9Z0J7 Mouse Unigene: 616962 Human Unigene: 31325 Mouse Unigene: 44228 Rat 生長分化因子15（GDF15）是骨形態(tài)發(fā)生蛋白（BMP）和轉(zhuǎn)化生長因子-β超家族成員。GDF-15又叫巨噬細(xì)胞抑制因子（macrophage inhibiting cytokine，MIC）-1、胎盤轉(zhuǎn)化生長因子 （placental transformation growth factor，PTGF）-β、前列腺衍生因子（prostate derived factor，PDF）和胎盤骨形態(tài)發(fā)生蛋白（placental bone morphogeneticprotein，PLAB）。 有學(xué)者認(rèn)為：GDF-15在腫瘤發(fā)展的不同階段發(fā)揮著不同的生物學(xué)作用；隨著腫瘤的發(fā)生發(fā)展，GDF-15可能表達(dá)不同形式的蛋白，在腫瘤發(fā)生的早期階段可能發(fā)揮抑瘤作用，而在腫瘤發(fā)展的后期階段發(fā)揮促瘤作用。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with GDF15 polyclonal antibody, unconjugated (bs-3818R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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