91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美婬乱片A片AAA毛片地址,少妇做爰毛片免费看视频一区二区
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
EIF2S1 Rabbit pAb (bs-3613R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號 bs-3613R
英文名稱 EIF2S1 Rabbit pAb
中文名稱 真核啟動因子2α抗體(eIFα2)抗體
別    名 EIF2A; CDA 02; CDA02; eIF 2 alpha; EIF 2; EIF 2A; EIF-2alpha; EIF2; EIF2alpha; eIF2S1; Eukaryotic Translation Initiation Factor 2 alpha; Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa; Eukaryotic translation initiation factor 2 subunit alpha; IF2A_HUMAN; eIF2α.  
Specific References  (13)     |     bs-3613R has been referenced in 13 publications.
[IF=9.988] Yue Zhang. et al. Endoplasmic reticulum stress-controlled autophagic pathway promotes polystyrene microplastics-induced myocardial dysplasia in birds. ENVIRON POLLUT. 2022 Oct;311:119963  WB ;  Chicken.  
[IF=7.129] Pengcheng Xing. et al. Cypermethrin and/or sulfamethoxazole exposure effect on apoptosis and endoplasmic reticulum of grass carp cardiomyocyte. ECOTOX ENVIRON SAFE. 2023 Mar;252:114594  WB ;  Mouse.  
[IF=6.175] Chen Yanan. et al. Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy. Journal of Animal Science and Biotechnology. 2022 Dec;13(1):1-16  WB ;  Human.  
[IF=5.714] Ting-Ting Yu. et al. Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage. INT IMMUNOPHARMACOL. 2023 Feb;115:109661  WB ;  Mouse,Human.  
[IF=5.168] He,et al.Modulation of inflammation by toll-like receptor 4/nuclear factor-kappa B in diarrhea-predominant irritable bowel syndrome.(2017) Oncotarget. 8:113957-113965.  WB ;  Rat.  
[IF=4.52] Zhu YP et al. Unification?of?Opposites?between?Two?Antioxidant?Transcription?Factors?Nrf1?and?Nrf2?in?Mediating?Distinct?Cellular?Responses?to the?Endoplasmic?Reticulum?Stressor?Tunicamycin. Antioxidants (Basel). 2019 Dec 19;9(1). pii: E4.  WB ;  Human.  
[IF=3.858] Li,et al.Silver nanoparticles induce SH-SY5Y cell apoptosis via endoplasmic reticulum- and mitochondrial pathways that lengthen endoplasmic reticulum-mitochondria contact sites and alter inositol-3-phosphate receptor function.(2018) Toxicology Letters. 285:156-167.  WB ;  Human.  
[IF=2.971] Wenfeng Gouet al. Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress. Pharm Biol . 2020 Dec;58(1):707-715.  WB ;  Human.  
[IF=2.776] Su M et al.Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress. (2019) Environ Toxicol Pharmacol.65:60-65.  WB ;  Mouse.  
[IF=2.77] Zuo Y et al. Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive dysfunction in aged rats. Behav Brain Res. 2019 Nov 5;373:112107.  WB ;  Rat.  
[IF=2.33] He, Yihuai, et al. "Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression." Molecular and Cellular Biochemistry (2014): 1-8.  WB ;  Human.  
[IF=2.147] Gurur Garip. et al. Effect of endoplasmic reticulum stress on human trophoblast cells: Survival triggering or catastrophe resulting in death. ACTA HISTOCHEM. 2022 Oct;124:151951  IF ;  Human.  
[IF=]   WB ;  fish.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Rat (predicted: Mouse,Rabbit,Pig,Cow,Chicken)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:200-800
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human eIF2 alpha: 75-180/315 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 eIF2 alpha is a 36 kDa protein which is ubiquitously expressed in many cell types. The eIF2 protein, which is composed of three subunits (alpha, beta and gamma), is one of the key molecules in the initiation of translation. In mammalian cells, eIF2 alpha is phosphorylated at serine 51 (human EIF2 alpha, the equivalent residue in mouse is serine 52) by at least two kinases: the haem-controlled repressor (HCR) and the interferon inducible double stranded RNA-dependent protein kinase (PKR). Phosphorylation of eIF2 alpha blocks the GDP-GTP exchange activity of eIF2 beta, resulting in the suppression of protein synthesis. The phosphorylation of eIF2 alpha is an important regulatory process in protein synthesis.

Function:
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Subunit:
Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation. Interacts with ABCF1 isoform 2. Associates with ribosomes.

Subcellular Location:
Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules.

Post-translational modifications:
Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A, eIF2S1 phosphorylation state is modulated.

Similarity:
Belongs to the eIF-2-alpha family.
Contains 1 S1 motif domain.

SWISS:
P05198

Gene ID:
1965

Database links:

Entrez Gene: 1965 Human

Entrez Gene: 13665 Mouse

Entrez Gene: 54318 Rat

Omim: 603907 Human

SwissProt: P05198 Human

SwissProt: Q6ZWX6 Mouse

SwissProt: P68101 Rat

Unigene: 151777 Human

Unigene: 196220 Mouse

Unigene: 1488 Rat



eIF2α(真核啟動因子2α)
產(chǎn)品圖片
Sample: Lane 1: A431 (Human) Cell Lysate at 30 ug Lane 2: Hela (Human) Cell Lysate at 30 ug Lane 3: Jurkat (Human) Cell Lysate at 30 ug Primary: Anti-EIF2S1/eIF2 alpha (bs-3613R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36-38 kD Observed band size: 35 kD
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (EIF2S1/eIF2 alpha) Polyclonal Antibody, Unconjugated (bs-3613R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat lung tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (eIF2 alpha) Polyclonal Antibody, Unconjugated (bs-3613R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining
版權(quán)所有 2004-2026 rvdoil.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
无遮挡已满视频在线观看 | 国产欧美一区二区三区沐欲 | 国产无码在线观看一区 | 欧洲精品视频在线黑寡妇幼 | 熟女乱婬AAAA片久久 | 国产精品色情国产二级 | 国产精品久久久久久一级毛皮陈红 | 国产成人做爰A片免费胖人 鲁鲁鲁A片1级毛片免费看 | 日韩成人在线观看 | 亚洲精品一区久久久久久 | 东北女人逼毛多水多大片 | 黄色视频观看免费在线 | 性爱69卖实少妇出规 | 敌伦交换一区二区三区 | 欧美大黑BBBBBBBBB香啊 | 亚洲乱码日产精品BD | 亚欧洲乱码国产色久一区二区三乱 | 成人午夜免费福利大片 | 91久久精品无码视频 | 又粗又黄的视频在线观看 | 中文字幕无码黄色视频 | 午夜福利视频免费观看 | 后入到高潮免费看 | 国产又黄又猛又粗又爽 | 人妻无码аⅴ天堂中文在线 | 人妻少妇被猛烈进入中文字幕 | 美女极品嫩苞无套内谢 | 国产aV级毛片特别刺激 | 国产精品 在线播放 | DVD人人人澡人人人爽 | 欧美日韩久久久精品A片妖精 | 国产高清无码100% | 午夜国产A久久片亚洲最大 影音先锋中文字幕在线观看 | 无码人妻一区二区三区免费九色 | 国产精品高清网站 | 国产最爽的乱婬绿帽3p | 亚洲伊人影院一区综合 | 中文字幕精品在线观看 | 国产精品多人高p无码 | 96国产揄拍国产精品人妻 | 亚洲AⅤ无码一区二区波多野BT |