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CACNB2 Rabbit pAb (bs-2996R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-2996R
英文名稱(chēng) CACNB2 Rabbit pAb
中文名稱(chēng) L-型電壓依賴(lài)型鈣通道β抗體
別    名 Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Cacnb2; Cacnlb2; VDCC-L beta; Calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; calcium channel beta 2c subunit; calcium channel L-type beta 2 subunit; CACB2_HUMAN.  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  通道蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 74 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CACNB2: 551-655/655 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subunit:
The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane.

Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Similarity:
Belongs to the calcium channel beta subunit family.
Contains 1 SH3 domain.

SWISS:
Q08289

Gene ID:
783

Database links:

Entrez Gene: 783 Human

Entrez Gene: 12296 Mouse

Entrez Gene: 116600 Rat

Omim: 600003 Human

SwissProt: Q08289 Human

SwissProt: Q8CC27 Mouse

SwissProt: Q8VGC3 Rat

Unigene: 59093 Human

Unigene: 313930 Mouse

Unigene: 10739 Rat



電壓依賴(lài)性鈣通道(VDCC)是生物體內(nèi)一大類(lèi)鈣通道蛋白,隨著膜電位的改變而出現(xiàn)通道的開(kāi)放、關(guān)閉和失活,調(diào)節(jié)細(xì)胞內(nèi)Ca2+濃度,最終產(chǎn)生生物學(xué)效應(yīng).其亞型結(jié)構(gòu)各異,VDCC β亞基具有調(diào)節(jié)其通道活性的作用,VDCC存在的普遍性決定了其作用的廣泛性.在胰腺、心、腦、腎上腺、視網(wǎng)膜及神經(jīng)等組織器官均有不同程度的分布.
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