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MTNR1A Rabbit pAb (bs-0027R)

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產(chǎn)品編號(hào)	bs-0027R
英文名稱	MTNR1A Rabbit pAb
中文名稱	褪黑素受體1A/松果體素受體1A抗體
別名	MTR1A_HUMAN; Melatonin receptor type 1A; Melatonin Receptor 1A; Mel-1A-R; Mel1a receptor; MT1; MT 1; Mel 1A R;
	Specific References (21) \| bs-0027R has been referenced in 21 publications. [IF=14.528] IF ; mouse. PubMed:32761924 [IF=14.528] Dejun Xu. et al. Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner. J Pineal Res. 2020 Nov;69(4):e12690 IF ; Mouse. PubMed:32761924 [IF=13.007] Shanshan Yu. et al. Melatonin prevents experimental central serous chorioretinopathy in rats. J PINEAL RES. 2022 Apr 29 WB,IHC ; Rat. PubMed:35436360 [IF=11.613] Han D et al. Activation of Melatonin Receptor 2 But Not Melatonin Receptor 1 Mediates Melatonin‐conferred Cardio‐protection Against Myocardial Ischemia/Reperfusion Injury.J Pineal Res. 2019 Mar 22:e12571. IHC-P,IF&WB ; Mouse. PubMed:30903623 [IF=10.39] Jang, Hoon, et al. "Synergistic effect of melatonin and ghrelin in preventing cisplatin‐induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles." Journal of Pineal Research (2017). IHC-P ; Mouse. PubMed:28658519 [IF=5.682] Gao Xinran. et al. Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms. MOL NEUROBIOL. 2023 May;:1-23 WB ; Mouse. PubMed:37126129 [IF=5.546] Donghui Yang. et al. Melatonin alleviates LPS‐induced endoplasmic reticulum stress and inflammation in spermatogonial stem cells. J Cell Physiol. 2021 May;236(5):3536-3551 WB,IF,IHC ; Mouse. PubMed:32996162 [IF=4.2] Yang, Wucai, et al. "Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes." Scientific Reports 7.1 (2017): 15080. WB ; Bovine. PubMed:29118419 [IF=3.468] Tang Qian. et al. The Effect of Melatonin on Radicular Pain in a Rat Model of Lumbar Disc Herniation. SPINE. 2022 May;47(10):754-763 WB ; Rat. PubMed:35102121 [IF=3.255] Hongwei Duan. et al. The effect of melatonin on sheep endometrial epithelial cell apoptosis through the receptor and non-receptor pathways. GEN COMP ENDOCR. 2022 Nov;:114182 IF ; Sheep. PubMed:36455642 [IF=3.04] Tabecka-Lonczyska, Anna, et al. "New insight on the role of melatonin receptors in reproductive processes of seasonal breeders on the example of mature male European bison (Bison bonasus, Linnaeus 1758)." Journal of Photochemistry and Photobiology B: Biology (2017). dot-blot, IHC-P ; Other Species. PubMed:28570908 [IF=2.923] Hongwei Duan. et al. Melatonin regulates dihydrotestosterone formation via its membrane receptor in the epididymal epithelial cells of sheep. THERIOGENOLOGY. 2022 Dec;: WB ; Sheep. PubMed:36623430 [IF=2.923] Junyuan Ma. et al. Effects of melatonin on development and hormone secretion of sheep theca cells in?vitro. THERIOGENOLOGY. 2023 Mar;198:172 IHC ; Sheep. PubMed:36592515 [IF=2.586] G?k?e Nur Ar?k. et al. Melatonin effective to reduce the microscopic symptoms of polycystic ovary syndrome-related infertility: An experimental study. TISSUE CELL. 2023 Jan;:102015 IHC ; Rat. PubMed:36657254 [IF=2.532] Arzu Yalcin. et al. Protective effect of melatonin on learning and memory impairment and hippocampal dysfunction in rats induced by high-fructose corn syrup. IRAN J BASIC MED SCI. 2023 Jan;26(1):69-75 WB ; Rat. PubMed:36594054 [IF=2.08] Wang, S-J., et al. "Melatonin suppresses apoptosis and stimulates progesterone production by bovine granulosa cells via its receptors (MT1 and MT2)." Theriogenology 78.7 (2012): 1517-1526. WB ; Bovine. PubMed:22980085 [IF=1.858] Wenbo Ge. et al. Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro. REPROD DOMEST ANIM. 2022 Aug;: IF, IHC ; Sheep. PubMed:36018566 [IF=1.778] Zhao Shu-Qin. et al. The in vitro effects of melatonin and Cry gene on the secretion of estradiol from camel ovarian granulosa cells. Domest Anim Endocrin. 2021 Jan;74:106497 WB,IF ; Camel. PubMed:32799039 [IF=1.778] S.-Q. Zhao. et al. cAMP/PKA/CREB signaling pathway-mediated effects of melatonin receptor genes on clock gene expression in Bactrian camel ovarian granulosa cells. Domest Anim Endocrin. 2021 Jul;76:106609 IHC ; Camel. PubMed:33636446 [IF=1.291] Gao Y et al. Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.Cell?Mol Biol Lett.?2019 Mar 12;24:21. IHC-P,IF&WB ; Mouse. PubMed:30915128 [IF=0.821] Sanghoon Lee. et al. Expression of the melatonergic system during meiotic maturation of cynomolgus monkey cumulus–oocyte complexes. J MED PRIMATOL. 2023 Mar;: ICC ; Monkey. PubMed:36973936
研究領(lǐng)域	腫瘤細(xì)胞生物神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體新陳代謝
抗體來(lái)源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Mouse,Rat (predicted: Human,Pig,Sheep,Cow,Dog)
產(chǎn)品應(yīng)用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	39 kDa
檢測(cè)分子量
細(xì)胞定位	細(xì)胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from the midlle of human MTNR1A: 201-280/350 <Cytoplasmic>
亞型	IgG
純化方法	affinity purified by Protein A
緩沖液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008] Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 4543 Database links: Entrez Gene: 4543 Human Omim: 600665 Human SwissProt: P48039 Human Unigene: 243467 Human 褪黑激素受體1A- 此抗體是MTR-1A特異性抗體，與MTR-1B無(wú)交叉反應(yīng)。MEL-1A-R除分布在視網(wǎng)膜和下丘腦外，還廣泛存在于多個(gè)組織中，也是有重著要生理活性的激素。
產(chǎn)品圖片	Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Pituitary tissue lysates Lane 3: Mouse Testis tissue lysates Lane 4: Rat Cerebrum tissue lysates Lane 5: Rat Pituitary tissue lysates Lane 6: Rat Eye tissue lysates Primary: Anti-MTNR1A (bs-0027R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kDa Observed band size: 55 kDa

	免疫組化常用試劑
	免疫印跡常用試劑
	各種標(biāo)記二抗

	1、抗體溶解方法
	2、抗體修復(fù)方式
	3、常用試劑的配制
	4、免疫組化操作步驟
	5、免疫組化問題解答
	6、Western Blotting 操作步驟
	7、Western Blotting 問題解答
	8、關(guān)于肽鏈的設(shè)計(jì)
	9、多肽的溶解與保存
	10、酶標(biāo)抗體效價(jià)測(cè)定程序

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