| 產(chǎn)品編號(hào) | bs-0343R |
| 英文名稱 | large S protein Rabbit pAb |
| 中文名稱 | 人乙肝病毒Large S蛋白抗體 |
| 別 名 | HBSAG_HBVC5; preS1/preS2/S; Hepatitis B Virus Surface Antigen; Large envelope protein; L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; Hepatitis B virus ad/Japan/S-179/1988. |
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Specific References (1) | bs-0343R has been referenced in 1 publications.
[IF=1.93] Yuan, Xiaocong. "A label-free approach to kinetic analysis and high multiplex detection of targeted drugs with phase surface plasmon resonance imaging."Analytical Methods (2015). other ;
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)菌及病毒 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Hepatitis B virus) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31/44 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from HBSAG_HBVC5: 201-281/281 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
HBV surface proteins [Hepatitis B virus]. Major surface antigen from hepadnavirus; pfam00695. Function: The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid. Subunit: Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. Subcellular Location: Virion membrane. Post-translational modifications: Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region. Myristoylated. Similarity: Belongs to the orthohepadnavirus major surface antigen family. Database links: SwissProt: P03140 Hepatitis B virus 乙型肝肝炎病毒顆粒直徑42nm，由包膜與核衣殼組成，包膜含有碳水化合物、蛋白質(zhì)和脂類。其中蛋白質(zhì)為主要抗原成分，包括S抗原：pre-s1區(qū)和pre-s2區(qū)，這些抗原成分在病毒侵入細(xì)胞過(guò)程中有著至關(guān)重要的作用，為深入研究乙型肝肝炎病毒發(fā)病機(jī)理及變異有著至關(guān)重要的作用。 |
